Peter Verhaert delivered an invited lecture on Development of different clinical top-down proteomics applications at the 2nd Top-Down Proteomics Symposium organized by the Biomedical Research Institute at Barcelona (Spain). Other Speakers at the symposium were Dr. Marina Gay, Prof. Luca Fornelli and Dr. Daniel Lopez-Ferrer.
Top-down protein mass spectrometry allows comprehensive characterization of proteoforms from complex mixtures and avoids many pitfalls associated with traditional bottom-up workflows. Moreover, proteoform analysis is strongly connected to diagnosis in complex phenotypes and can be key in clinical applications.
We will present several examples of top-down mass spectrometry for its use in translational proteomics and the latest advances in the field with Orbitrap instruments.
You can browse the full programme at https://www.irbbarcelona.org/en/events/top-down-mass-spectrometry-meeting-0.